| Rafael Nadal (1) | Bye | | | | | | |
| Bye | - | Rafael Nadal (1) | 6 6 | | | | |
| Andreas Haider-Maurer | 2 4 | Roberto Carballes Baena | 4 4 | | | | |
| Roberto Carballes Baena | 6 6 | | | Rafael Nadal (1) | 6 6 | | |
| Yuichi Sugita | 6(5) 6(5) | | | Guillermo Garcia-Lopez | 1 3 | | |
| Guillermo Garcia-Lopez | 7(7) 7(7) | Guillermo Garcia-Lopez | 6 | | | | |
| Bye | - | Kei Nishikori (14) | 3 ret. | | | | |
| Kei Nishikori (14) | Bye | | | | | Rafael Nadal (1) | 6 7 |
| Feliciano Lopez (12) | Bye | | | | | Martin Klizan | 0 5 |
| Bye | - | Feliciano Lopez (12) | 6 2 6 | | | | |
| Pedro Martinez | 4 7(7) 3 | Dusan Lajovic | 4 6 4 | | | | |
| Dusan Lajovic | 6 6(5) 6 | | | Feliciano Lopez (12) | 1 4 | | |
| Martin Klizan | 6 6(5) 6 | | | Martin Klizan | 6 6 | | |
| Federico Delbonis | 3 7(7) 4 | Martin Klizan | 6 1 6 | | | | |
| Bye | - | Novak Djokovic (16) | 2 6 3 | | | | |
| Novak Djokovic (16) | Bye | | | | | | |
| David Goffin (4) | Bye | | | | | | |
| Bye | - | David Goffin (4) | 4 7(7) 6 | | | | |
| Mikhail Kukushkin | 2 2 | Marcel Granollers | 6 6(2) 2 | | | | |
| Marcel Granollers | 6 6 | | | David Goffin (4) | 2 7(7) 6 | | |
| Leonardo Mayer | 6 6 | | | Karen Khachanov (16) | 6 6(2) 0 | | |
| Mischa Zverev | 3 0 | Leonardo Mayer | 4 3 | | | | |
| Bye | - | Karen Khachanov (16) | 6 6 | | | | |
| Karen Khachanov (16) | Bye | | | | | David Goffin (4) | 6(3) 6 6 |
| Pablo Andujar | Bye | | | | | Roberto Bautista Agut (8) | 7(7) 2 2 |
| Bye | - | Pablo Andujar | 6 6 | | | | |
| Bjorn Fratangelo | 7 5 6 | Bjorn Fratangelo | 4 3 | | | | |
| Alexey Vatutin | 5 7 3 | | | Pablo Andujar | 4 1 | | |
| Tommy Robredo | 7(7) 6(08) 4 | | | Roberto Bautista Agut (8) | 6 6 | | |
| Ivo Karlovic | 6(5) 7(10) 6 | Ivo Karlovic | 7(7) 2 4 | | | | |
| Bye | - | Roberto Bautista Agut (8) | 6(4) 6 6 | | | | |
| Roberto Bautista Agut (8) | Bye | | | | | | |
| Diego Schwartzman (7) | Bye | | | | | | |
| Bye | - | Diego Schwartzman (7) | 2 1 | | | | |
| Corentin Moutet | 4 1 | Stefanos Tsitsipas | 6 6 | | | | |
| Stefanos Tsitsipas | 6 6 | | | Stefanos Tsitsipas | 6 7 | | |
| Jared Donaldson | 3 1 | | | Albert Ramos-Vinolas (10) | 4 5 | | |
| Rogerio Dutra Silva | 6 6 | Rogerio Dutra Silva | 6 3 4 | | | | |
| Bye | - | Albert Ramos-Vinolas (10) | 3 6 6 | | | | |
| Albert Ramos-Vinolas (10) | Bye | | | | | Stefanos Tsitsipas | 6 6 |
| Jozef Kovalik | Bye | | | | | Dominic Thiem (3) | 3 2 |
| Bye | - | Jozef Kovalik | 6 6 | | | | |
| Peter Gojowczyk | 4 4 | Guido Pella | 3 3 | | | | |
| Guido Pella | 6 6 | | | Jozef Kovalik | 6(5) 2 | | |
| Jaume Munar | 6 3 7 | | | Dominic Thiem (3) | 7(7) 6 | | |
| Joao Sousa | 4 6 5 | Jaume Munar | 6(08) 1 | | | | |
| Bye | - | Dominic Thiem (3) | 7(10) 6 | | | | |
| Dominic Thiem (3) | Bye | | | | | | |
| Pablo Carreno Busta (5) | Bye | | | | | | |
| Bye | - | Pablo Carreno Busta (5) | 6 6 | | | | |
| Benoit Paire | 7(7) 6(3) 6 | Benoit Paire | 3 3 | | | | |
| Nicolas Jarry | 6(4) 7(7) 4 | | | Pablo Carreno Busta (5) | 6 4 7(8) | | |
| Ricardo Ojeda Lara | 0 4 | | | Adrian Mannarino (11) | 2 6 6(6) | | |
| Pablo Cuevas | 6 6 | Pablo Cuevas | 4 6(5) | | | | |
| Bye | - | Adrian Mannarino (11) | 6 7(7) | | | | |
| Adrian Mannarino (11) | Bye | | | | | Pablo Carreno Busta (5) | 6 7(7) |
| Ernesto Escobedo | Bye | | | | | Grigor Dimitrov (2) | 3 6(4) |
| Bye | - | Ernesto Escobedo | 4 3 | | | | |
| Tennys Sandgren | 4 4 | Malek Jaziri | 6 6 | | | | |
| Malek Jaziri | 6 6 | | | Malek Jaziri | 5 6 6(08) | | |
| Ilya Ivashka | 2 3 | | | Grigor Dimitrov (2) | 7 3 7(10) | | |
| Gilles Simon | 6 6 | Gilles Simon | 2 1 | | | | |
| Bye | - | Grigor Dimitrov (2) | 6 6 | | | | |
| Grigor Dimitrov (2) | Bye | | | | | | |
