| Roger Federer (1) | Bye | | | | | | |
| Bye | - | Roger Federer (1) | 6 3 6(4) | | | | |
| Calvin Hemery | 1 2 | Thanasi Kokkinakis | 3 6 7(7) | | | | |
| Thanasi Kokkinakis | 6 6 | | | Thanasi Kokkinakis | 6 4 6(4) | | |
| Guillermo Garcia-Lopez | 7(7) 7(8) | | | Fernando Verdasco (31) | 3 6 7(7) | | |
| Tennys Sandgren | 6(3) 6(6) | Guillermo Garcia-Lopez | 6 0 2 | | | | |
| Bye | - | Fernando Verdasco (31) | 4 6 6 | | | | |
| Fernando Verdasco (31) | Bye | | | | | Fernando Verdasco (31) | 0 3 |
| Adrian Mannarino (18) | Bye | | | | | Pablo Carreno Busta (16) | 6 6 |
| Bye | - | Adrian Mannarino (18) | 3 3 | | | | |
| Steve Johnson | 6 6 | Steve Johnson | 6 6 | | | | |
| Victor Estrella Burgos | 3 3 | | | Steve Johnson | 4 4 | | |
| Denis Istomin | 7 6 | | | Pablo Carreno Busta (16) | 6 6 | | |
| Miomir Kecmanovic | 5 4 | Denis Istomin | 1 0 | | | | |
| Bye | - | Pablo Carreno Busta (16) | 6 6 | | | | |
| Pablo Carreno Busta (16) | Bye | | | | | | |
| Tomas Berdych (10) | Bye | | | | | | |
| Bye | - | Tomas Berdych (10) | 6 6 | | | | |
| Alex De Minaur | 2 4 | Yoshihito Nishioka | 1 4 | | | | |
| Yoshihito Nishioka | 6 6 | | | Tomas Berdych (10) | 7(7) 2 6(1) | | |
| Nicolas Kicker | 3 6(4) | | | Frances Tiafoe | 6(2) 6 7(7) | | |
| Frances Tiafoe | 6 7(7) | Frances Tiafoe | 7(7) 4 7(7) | | | | |
| Bye | - | Kyle Edmund (21) | 6(4) 6 6(5) | | | | |
| Kyle Edmund (21) | Bye | | | | | Frances Tiafoe | 6(3) 4 |
| Karen Khachanov (32) | Bye | | | | | Kevin Anderson (6) | 7(7) 6 |
| Bye | - | Karen Khachanov (32) | 7 6 | | | | |
| Marius Copil | 7(7) 6 | Marius Copil | 5 3 | | | | |
| Mikhail Kukushkin | 6(2) 4 | | | Karen Khachanov (32) | 6 2 3 | | |
| Thomas Fabbiano | 6 2 5 | | | Kevin Anderson (6) | 4 6 6 | | |
| Nikoloz Basilashvili | 1 6 7 | Nikoloz Basilashvili | 4 3 | | | | |
| Bye | - | Kevin Anderson (6) | 6 6 | | | | |
| Kevin Anderson (6) | Bye | | | | | | |
| Alexander Zverev (4) | Bye | | | | | | |
| Bye | - | Alexander Zverev (4) | 6 1 7(7) | | | | |
| Stefanos Tsitsipas | 6 4 2 | Daniil Medvedev | 4 6 6(5) | | | | |
| Daniil Medvedev | 2 6 6 | | | Alexander Zverev (4) | 2 6 6 | | |
| Evgeny Donskoy | 7 6 | | | David Ferrer (28) | 6 2 4 | | |
| Aljaz Bedene | 5 4 | Evgeny Donskoy | 2 2 | | | | |
| Bye | - | David Ferrer (28) | 6 6 | | | | |
| David Ferrer (28) | Bye | | | | | Alexander Zverev (4) | 6 6 |
| Nick Kyrgios (17) | Bye | | | | | Nick Kyrgios (17) | 4 4 |
| Bye | - | Nick Kyrgios (17) | 6 6 | | | | |
| Dusan Lajovic | 3 7(7) 6 | Dusan Lajovic | 4 1 | | | | |
| Horacio Zeballos | 6 6(2) 4 | | | Nick Kyrgios (17) | 6 6 | | |
| Nicola Kuhn | 7(7) 6 | | | Fabio Fognini (15) | 3 3 | | |
| Darian King | 6(4) 4 | Nicola Kuhn | 2 4 | | | | |
| Bye | - | Fabio Fognini (15) | 6 6 | | | | |
| Fabio Fognini (15) | Bye | | | | | | |
| Sam Querrey (11) | Bye | | | | | | |
| Bye | - | Sam Querrey (11) | 7(7) 6 | | | | |
| Ricardas Berankis | 1 6 6(4) | Radu Albot | 6(4) 1 | | | | |
| Radu Albot | 6 4 7(7) | | | Sam Querrey (11) | 4 6 5 | | |
| Denis Shapovalov | 6 6(4) 7(8) | | | Denis Shapovalov | 6 3 7 | | |
| Viktor Troicki | 3 7(7) 6(6) | Denis Shapovalov | 6 7 | | | | |
| Bye | - | Damir Dzumhur (24) | 1 5 | | | | |
| Damir Dzumhur (24) | Bye | | | | | Denis Shapovalov | 6(2) 6 4 |
| Borna Coric (29) | Bye | | | | | Borna Coric (29) | 7(7) 4 6 |
| Bye | - | Borna Coric (29) | 6(5) 6 6 | | | | |
| Leonardo Mayer | 3 6 6 | Leonardo Mayer | 7(7) 3 4 | | | | |
| Donald Young | 6 4 2 | | | Borna Coric (29) | 5 7(7) 6 | | |
| Yuki Bhambri | 7 6 | | | Jack Sock (8) | 7 6(4) 3 | | |
| Mirza Basic | 5 3 | Yuki Bhambri | 3 6(3) | | | | |
| Bye | - | Jack Sock (8) | 6 7(7) | | | | |
| Jack Sock (8) | Bye | | | | | | |
| Juan Martin Del Potro (5) | Bye | | | | | | |
| Bye | - | Juan Martin Del Potro (5) | 6 5 6 | | | | |
| Yuichi Sugita | 4 6 1 | Robin Haase | 4 7 2 | | | | |
| Robin Haase | 6 3 6 | | | Juan Martin Del Potro (5) | 6 6 | | |
| John Millman | 2 6 6 | | | Kei Nishikori (26) | 2 2 | | |
| Peter Gojowczyk | 6 4 4 | John Millman | 6(4) 6 3 | | | | |
| Bye | - | Kei Nishikori (26) | 7(7) 4 6 | | | | |
| Kei Nishikori (26) | Bye | | | | | Juan Martin Del Potro (5) | 6 6 |
| Filip Krajinovic (22) | Bye | | | | | Filip Krajinovic (22) | 4 2 |
| Bye | - | Filip Krajinovic (22) | 6 6 | | | | |
| Bjorn Fratangelo | 6(5) 3 | Liam Broady | 3 2 | | | | |
| Liam Broady | 7(7) 6 | | | Filip Krajinovic (22) | 6 6 | | |
| Mischa Zverev | 6 1 2 | | | Benoit Paire | 3 3 | | |
| Benoit Paire | 1 6 6 | Benoit Paire | 6 6 | | | | |
| Bye | - | Novak Djokovic (9) | 3 4 | | | | |
| Novak Djokovic (9) | Bye | | | | | | |
| Diego Schwartzman (13) | Bye | | | | | | |
| Bye | - | Diego Schwartzman (13) | 6 6 | | | | |
| Cameron Norrie | 6(3) 2 | Nicolas Jarry | 3 1 | | | | |
| Nicolas Jarry | 7(7) 6 | | | Diego Schwartzman (13) | 6(5) 3 | | |
| Mikael Ymer | 3 7 6 | | | Milos Raonic (20) | 7(7) 6 | | |
| Jan-Lennard Struff | 6 5 1 | Mikael Ymer | 3 3 | | | | |
| Bye | - | Milos Raonic (20) | 6 6 | | | | |
| Milos Raonic (20) | Bye | | | | | Milos Raonic (20) | 6 6 |
| Richard Gasquet (30) | Bye | | | | | Jeremy Chardy | 3 4 |
| Bye | - | Richard Gasquet (30) | 5 1 | | | | |
| Jeremy Chardy | 6 7(7) | Jeremy Chardy | 7 6 | | | | |
| Rogerio Dutra Silva | 3 6(2) | | | Jeremy Chardy | 6 6 | | |
| Marton Fucsovics | 4 4 | | | Grigor Dimitrov (3) | 4 4 | | |
| Maximilian Marterer | 6 6 | Maximilian Marterer | 6 2 1 | | | | |
| Bye | - | Grigor Dimitrov (3) | 4 6 6 | | | | |
| Grigor Dimitrov (3) | Bye | | | | | | |
| David Goffin (7) | Bye | | | | | | |
| Bye | - | David Goffin (7) | 0 1 | | | | |
| Ryan Harrison | 6(4) 6(4) | Joao Sousa | 6 6 | | | | |
| Joao Sousa | 7(7) 7(7) | | | Joao Sousa | 1 6 6 | | |
| Jared Donaldson | 6 6 | | | Jared Donaldson | 6 3 4 | | |
| Marcos Baghdatis | 3 4 | Jared Donaldson | 6 6 | | | | |
| Bye | - | Feliciano Lopez (25) | 4 2 | | | | |
| Feliciano Lopez (25) | Bye | | | | | Joao Sousa | 4 3 |
| Hyeon Chung (19) | Bye | | | | | Hyeon Chung (19) | 6 6 |
| Bye | - | Hyeon Chung (19) | 6 7 | | | | |
| Matthew Ebden | 6 6(2) 7 | Matthew Ebden | 3 5 | | | | |
| Gilles Simon | 3 7(7) 5 | | | Hyeon Chung (19) | 6 6 | | |
| Christopher Eubanks | 6 4 4 | | | Michael Mmoh | 1 1 | | |
| Michael Mmoh | 4 6 6 | Michael Mmoh | 7(7) 2 6 | | | | |
| Bye | - | Roberto Bautista Agut (12) | 6(4) 6 4 | | | | |
| Roberto Bautista Agut (12) | Bye | | | | | | |
| John Isner (14) | Bye | | | | | | |
| Bye | - | John Isner (14) | 7(7) 1 6 | | | | |
| Jiri Vesely | 7(7) 6 | Jiri Vesely | 6(3) 6 3 | | | | |
| Lukas Lacko | 6(2) 3 | | | John Isner (14) | 6 6 | | |
| Guido Pella | 6(3) 6(2) | | | Mikhail Youzhny | 4 3 | | |
| Mikhail Youzhny | 7(7) 7(7) | Mikhail Youzhny | 4 6 6 | | | | |
| Bye | - | Gilles Muller (23) | 6 4 2 | | | | |
| Gilles Muller (23) | Bye | | | | | John Isner (14) | 7(7) 6 |
| Andrey Rublev (27) | Bye | | | | | Marin Cilic (2) | 6(0) 3 |
| Bye | - | Andrey Rublev (27) | 6(5) 4 | | | | |
| Ivo Karlovic | 6(4) 6(5) | Vasek Pospisil | 7(7) 6 | | | | |
| Vasek Pospisil | 7(7) 7(7) | | | Vasek Pospisil | 5 6(4) | | |
| Pierre-Hugues Herbert | 7(7) 6 | | | Marin Cilic (2) | 7 7(7) | | |
| Taylor Fritz | 6(4) 4 | Pierre-Hugues Herbert | 5 3 | | | | |
| Bye | - | Marin Cilic (2) | 7 6 | | | | |
| Marin Cilic (2) | Bye | | | | | | |
