| Rafael Nadal (1) | Bye | | | | | | |
| Bye | - | Rafael Nadal (1) | 6(7) 6 6 | | | | |
| Marius Copil | 3 7(7) 5 | Leonardo Mayer | 7(9) 4 2 | | | | |
| Leonardo Mayer | 6 6(3) 7 | | | Rafael Nadal (1) | 6 6 | | |
| David Ferrer | 6 6 | | | David Ferrer | 3 3 | | |
| Mischa Zverev | 3 1 | David Ferrer | 6 6 | | | | |
| Bye | - | Lucas Pouille (15) | 3 1 | | | | |
| Lucas Pouille (15) | Bye | | | | | Rafael Nadal (1) | 7 7 |
| David Goffin (10) | Bye | | | | | Jan-Lennard Struff | 5 5 |
| Bye | - | David Goffin (10) | 6(6) 3 | | | | |
| Hugo Dellien | 3 1 | Jan-Lennard Struff | 7(8) 6 | | | | |
| Jan-Lennard Struff | 6 6 | | | Jan-Lennard Struff | 6 3 6 | | |
| Marton Fucsovics | 6 6 | | | Stefanos Tsitsipas (5) | 4 6 2 | | |
| Denis Kudla | 4 1 | Marton Fucsovics | 3 4 | | | | |
| Bye | - | Stefanos Tsitsipas (5) | 6 6 | | | | |
| Stefanos Tsitsipas (5) | Bye | | | | | | |
| Dominic Thiem (3) | Bye | | | | | | |
| Bye | - | Dominic Thiem (3) | 6 6 | | | | |
| Yoshihito Nishioka | 6 4 2 | Diego Schwartzman | 3 3 | | | | |
| Diego Schwartzman | 4 6 6 | | | Dominic Thiem (3) | 7 6 | | |
| Pedro Sousa | 6 4 0 | | | Jaume Munar | 5 1 | | |
| Jaume Munar | 2 6 6 | Jaume Munar | 6 6 | | | | |
| Bye | - | Frances Tiafoe (14) | 4 3 | | | | |
| Frances Tiafoe (14) | Bye | | | | | Dominic Thiem (3) | 7 6 |
| Pablo Carreno Busta (12) | Bye | | | | | Guido Pella | 5 2 |
| Bye | - | Pablo Carreno Busta (12) | 4 7(11) 1 | | | | |
| Juan Ignacio Londero | 5 2 | Benoit Paire | 6 6(09) 6 | | | | |
| Benoit Paire | 7 6 | | | Benoit Paire | 5 3 | | |
| Guido Pella | 3 7(7) 6 | | | Guido Pella | 7 6 | | |
| Joao Sousa | 6 6(1) 2 | Guido Pella | 6 7(7) | | | | |
| Bye | - | Karen Khachanov (6) | 2 6(4) | | | | |
| Karen Khachanov (6) | Bye | | | | | | |
| Roberto Carballes Baena | Bye | | | | | | |
| Bye | - | Roberto Carballes Baena | 6(4) 6 6 | | | | |
| Nicola Kuhn | 7(7) 4 6 | Nicola Kuhn | 7(7) 4 2 | | | | |
| Federico Delbonis | 6(3) 6 2 | | | Roberto Carballes Baena | 6 7(7) | | |
| Martin Klizan | 5 4 | | | Christian Garin | 4 6(2) | | |
| Christian Garin | 7 6 | Christian Garin | 7 6 | | | | |
| Bye | - | Denis Shapovalov (9) | 5 2 | | | | |
| Denis Shapovalov (9) | Bye | | | | | Roberto Carballes Baena | 4 5 |
| Felix Auger-Aliassime (16) | Bye | | | | | Kei Nishikori (4) | 6 7 |
| Bye | - | Felix Auger-Aliassime (16) | 6 7(9) | | | | |
| Malek Jaziri | 6(3) 6 6 | Malek Jaziri | 3 6(7) | | | | |
| Guido Andreozzi | 7(7) 4 2 | | | Felix Auger-Aliassime (16) | 1 3 | | |
| Taylor Fritz | 6 6 | | | Kei Nishikori (4) | 6 6 | | |
| Reilly Opelka | 3 4 | Taylor Fritz | 5 2 | | | | |
| Bye | - | Kei Nishikori (4) | 7 6 | | | | |
| Kei Nishikori (4) | Bye | | | | | | |
| Daniil Medvedev (7) | Bye | | | | | | |
| Bye | - | Daniil Medvedev (7) | 6 2 6 | | | | |
| Albert Ramos-Vinolas | 6 6 | Albert Ramos-Vinolas | 3 6 1 | | | | |
| Cameron Norrie | 2 2 | | | Daniil Medvedev (7) | 6 6 | | |
| Mackenzie McDonald | 6 6 | | | Mackenzie McDonald | 3 2 | | |
| Taro Daniel | 2 2 | Mackenzie McDonald | 6 6 | | | | |
| Bye | - | Gilles Simon (11) | 3 2 | | | | |
| Gilles Simon (11) | Bye | | | | | Daniil Medvedev (7) | 6 6 |
| Grigor Dimitrov (13) | Bye | | | | | Nicolas Jarry | 3 4 |
| Bye | - | Grigor Dimitrov (13) | 6 6(4) 6 | | | | |
| Feliciano Lopez | 4 3 | Fernando Verdasco | 2 7(7) 3 | | | | |
| Fernando Verdasco | 6 6 | | | Grigor Dimitrov (13) | 6 4 6(2) | | |
| Nicolas Jarry | 7 4 6 | | | Nicolas Jarry | 2 6 7(7) | | |
| Marcel Granollers | 5 6 4 | Nicolas Jarry | 3 7 7(7) | | | | |
| Bye | - | Alexander Zverev (2) | 6 5 6(5) | | | | |
| Alexander Zverev (2) | Bye | | | | | | |
